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Celebration 2011

CCTEC hosted a New Business & Emerging Technology Showcase on April 14th, 2011 from 1-3 pm in the Statler Ballroom. The showcase featured exciting technologies and new business opportunities from the Ithaca campus, New York State Agricultural Experiment Station in Geneva, and Weill Cornell Medical College in New York City. Researchers and business representatives were on hand to discuss the technologies and companies. The New Business & Emerging Technology Showcase is part of the annual Entrepreneurship@Cornell Celebration event. Celebration is a milestone annual event that brings together over 900 alumni, faculty, students, and staff.


Agriculture & Plant Varieties


Farmer’s Daughter Honeydew Melon

  1. Michael Glos
    Plant Breeding & Genetics
    Michael Mazourek
    Plant Breeding & Genetics
    George Moriarty
    Plant Breeding & Genetics

    ‘Farmer’s Daughter’ Honeydew is a powdery mildew resistant variety that is the result of six years of selecting from crosses between ‘Collective Farmwomen’ and disease resistant Cornell breeding lines. When the fruit is mature, the stem easily pulls off, also referred to as, “slip”, a sign that the fruit is ripe. The melon ripens in 80-85 days. The fruit has a crisp white flesh with an excellent taste and pear-like flavor.

Hybrid Organic Corn

  1. Margaret Smith
    Plant Breeding & Genetics

    Cornell’s new Organic Corn Hybrid D2901 is a double cross corn hybrid that involves two public inbreds and two Cornell-developed inbreds. It has been tested on organic farms in New York and performs reasonably under stress conditions. Seed can be produced organically due to the vigor of the (hybrid) seed parents. It is classified as a 90-day hybrid, a maturity where organic hybrid variety options are limited.

Methods for Enhancing Lignin Depolymerization

  1. Stephane Corgie
    Biological &: Environmental Engineering
    Emmanuel Giannelis
    Materials Science & Engineering
    Patarawan Kahawong
    Materials Science & Engineering
    Larry Walker
    Biological & Environmental Engineering

    With the expanding need for transportation fuels and development of lignocellulosic biofuels, it is becoming obvious that a maximized usage of the whole plant biomass is needed for economic, logistic and sustainability reasons. This invention applies the enhanced ligninolytic activities of novel complexes to the depolymerisation of lignin and production of monomers as the source for bioproducts.

New Red Raspberry

  1. Courtney Weber
    Horticultural Sciences

    Red Raspberry ‘Crimson Giant’ is a primocane or more than one “crop” bearing fruits on current–season canes. It is primarily adapted to growing conditions of west central New York and other regions of similar climate. The new variety is characterized by sturdy upright canes growing in a crown formation. It is has very late primocane production. The fruit are bright red in color, very large, and conical in shape.

New Promoter Improves Quality of Fruit

  1. Geza Hrazdina
    Food Science & Technology, Cornell University

    This newly identified promoter can be used to improve fruit quality or traits. It drives the expression of a fruit ripening specific expansin gene. The promoter ensures fruit can be harvested at a later stage and therefore higher nutritional qualities are maintained. This promoter also improves the storage time of fruit from the resulting transgenic plants.

Biomedical/Bioengineering


Aptamer-Based Fluorescent Sensor Technology

  1. Samie Jaffrey
    Pharmacology

    Messenger RNA (mRNA) is regulated by a complex and intricate network of intracellular structures that have a critical role in gene expression. Recent studies have shown that new intracellular structures have roles in regulating the processing of RNAs, and it is clear that during RNA processing and maturation, transcripts traffic through different parts of the cell. Intracellular movement or location of proteins can be observed by fusing the protein of interest to the green fluorescent protein, GFP, but there are currently no analogous simple and straightforward approaches to track RNA movement in living cells, and currently available approaches have critical limitations that have precluded their widespread use.

Diagnosis, Prevention and Treatment of Crohn's Disease

  1. Belgin Dogan
    Clinical Sciences
    Kenneth Simpson
    Clinical Sciences

    Long polar fimbriae subunit A (LpfA) of E. coli can be used as a therapeutic target in both human and bovine diseases. Cornell researchers found LpfA to be a key virulence factor in human ileal-associated E. coli diseases, and E. coli strains isolated from milk of cows exhibiting diseases caused by the bacteria contain genes with homology to LpfA. This technology finds applications in treatment of both human and bovine diseases. In veterinary medicine, LpfA represents a novel therapeutic target to prevent and treat two E. coli-mediated diseases in cows: mastitis and metritis. In human medicine, LpfA can be used as a therapeutic target to prevent and treat inflammatory bowel diseases.

Fusion Protein in Prostate Cancer

  1. David Rickman
    Pathology
    Mark Rubin
    Pathology

    The majority of prostate cancers harbor gene fusions involving the erythroblast transformation specific (ETS) family of transcription factors. Further, both molecular and clinical data suggest that cancers exhibiting such a translocation represent a distinct molecular subclass that is characterized by an aggressive natural history. A new gene fusion has been identified. This gene fusion can be diagnostically and prognostically useful for prostate cancer management.

Method to Treat Autoimmune Diseases

  1. Norman Latov
    Neurology
    Grace Lee
    Neurology

    Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system that results in sensory loss. The main treatment for this disease is administration of intravenous immune globulin (IVIG), which can have serious side effects. An antibody-based method to inhibit autoimmune demyelinating neuropathy and other autoimmune or inflammatory diseases has been developed. This method also has therapeutic potential, particularly in the treatment of autoimmune diseases.

Molecular Profiling to Improve Classification of Thyroid Tumor Types

  1. Nimmi Arora
    Surgery
    Thomas Fahey
    Surgery
    Theresa Scognamiglio
    Pathology
    Rasa Zarnegar
    Surgery

    A group of 61 genes can be used in microarray analysis, that not only discriminate between benign and malignant tumors, but also identify a new class which they call "follicular adenomas with nuclear atypia (FANA)", which appear to be pre-malignant tumors. These tumors, not previously classified, have a distinct molecular profile and may represent an early stage in the progression of benign nodules to malignancies. Since current methods cannot accurately discriminate thyroid tumors, this molecular analysis can aid in further classification, possibly avoiding overly aggressive treatment.

Novita Pharmaceuticals, Inc.

  1. Novita Pharmaceuticals, Inc. is developing new drug molecules to prevent cancer metastasis by targeting a new gene target, fascin. The novel drug candidate molecules and gene target resulted from the work of a professor at Weill Cornell Medical College. These drug molecules are currently in pre-clinical development.

SaltCheck, Inc.

  1. SaltCheck is developing and commercializing a new patient salt intake monitoring system that does not require laboratory facilities. Regular monitoring of salt intake is an important factor in the control of hypertension and congestive heart failure. SaltCheck will be developing a technology for use in doctor offices, clinics, and at-home on a worldwide basis. This novel technology is based on research done at Weill Cornell Medical College.

Stealth Peptides, Inc.

  1. Stealth Peptides, is a clinical stage biopharmaceutical company developing novel and innovative mitochondrial targeted therapies for diseases with clear unmet medical needs including cardio-renal and metabolic disorders. Stealth was founded in 2006 with technology for a unique class of compounds licensed from Weill Cornell Medical College. Stealth’s first clinical candidate is Bendavia™, a compound that targets the mitochondria to treat ischemia reperfusion injury, a common complication of interventional procedures for acute myocardial infarction. A recently concluded first-in-human Phase I clinical trial evaluated the clinical safety, tolerability and pharmacokinetics of Bendavia™ in healthy volunteers.

Treatment for Skin Disorders

  1. Jochen Buck
    Pharmacology
    Lonny Levin
    Pharmacology
    Jonathan Zippin
    Dermatology

    A new treatment for skin disorders including psoriasis, cancer, and warts, has been developed. Current treatments include steroids, keratolytics, antharalin and coal tar, retinoids, and vitamin D. Some drawbacks of these topical therapies include staining clothes and skin, causing hypercalcemia (too much calcium in the blood), and irritating skin. This new treatment will block soluble adenylyl cyclase, a protein that is over-expressed in these skin disorders.

Life Sciences


An Assay and Potential Treatment for Obesity and Diabetes

  1. Hening Lin
    Chemistry & Chemical Biology

    Cornell researchers have developed a high-throughput activity assay that can be used to screen for small molecules that can regulate the activity of human sirtuin 6 (SIRT6), one of the seven human sirtuins, a class of proteins that regulate cell activity and biological pathways. Specific inhibitors of SIRT6 can potentially find use in treatment for obesity and diabetes. Lack of information on the activity of SIRT6 has been a major block for development of SIRT6 inhibitors and activators. The present invention represents a breakthrough that can open doors for treatments of obesity and diabetes.

Glycobia, Inc.

  1. Glycobia, Inc. is a biotechnology company spun out of Cornell University. Glycobia has a low-cost strategy for efficient production of a class of human drugs called therapeutic glycoproteins. Their technology platform seeks to revolutionize the multibillion-dollar enterprise surrounding the manufacture of these biopharmaceuticals for the treatment of diseases ranging from cancer to multiple sclerosis. Glycobia’s microbial technology circumvents the problems associated with existing and emerging platform technologies.

Medical Uses of Novel Polymers in Wound Healing and Surgical Procedures

  1. David Putnam
    Biomedical Engineering

    Post operative tissue adhesion can cause significant complications and often results in additional surgical procedures to remove the adhesions. Current solutions to prevent adhesion formation are limited due to their inflexible handling characteristics and inconsistent efficacies. This invention provides biopolymers that can be used for prevention or reduction of tissue adhesion, offering desirable flexibility in the surgical environment.

Method for Fully Incorporated Heme for Therapeutic Proteins and Research

  1. Brian Crane
    Chemistry & Chemical Biology

    A method that provides complete heme incorporation into recombinant proteins, greatly improving their functionality has been developed. Heme, a component of hemoglobin in blood, is not normally incorporated easily into recombinant proteins. This technology solves the issue and can potentially be used in therapeutic protein manufacturing and in research applications.

Tools for Disease Treatment

  1. Hening Lin
    Chemistry & Chemical Biology

    Human cells have seven sirtuins, which have been shown to regulate a variety of biological processes such as aging, transcription, and metabolism. While there is current understanding about the activity of sirtuins one through three, less is known about the functions of sirtuins four through seven. Cornell researchers have made a breakthrough discovery that sirtuin 5 (SIRT5) has unique enzymatic activity and specific inhibitors. Based on this discovery, a new fluorogenic assay was developed, opening the doors for research on SIRT5-specific inhibitors or activators that have potential to be valuable tools for investigating the function of SIRT5 and for disease treatment.

Physical Sciences


3D Food Printer

  1. Hod Lipson
    Mechanical & Aerospace Engineering
    Jeffrey Lipton
    Mechanical Engineering

    A 3D printer is able to “print” food when attached to a computer. The user gives the computer the information - a shape, a description of how the shape will be made, and a description of how the material works. The printer’s syringes can be filled up with raw food of liquid consistency and the syringes will “print” with the material. This do-it-yourself technology is a safe, easy to clean, and useful method for 3D printing and cooking foods.

Bacterial Cellulose based “Green” Composites

  1. Anil Netravali
    Fiber Science & Apparel Design
    Kaiyan Qiu
    Fiber Science & Apparel Design

    The high cost of bacterial cellulose (BC) production has been a major factor in limiting its use, but a new process allows the use of inexpensive carbon sources. This process opens the door to low-cost environmentally-friendly nano-composites. Nanocomposites are used in health care including artificial skin and tissue, paper, and textiles. Advantages of this method include high purity and crystallinity, high tensile strength, and biological adaptability.

Blocking Master Volleyball Tool

  1. Olena Gutor
    Athletics & Physical Education

    Blocking Master is a compact, portable, and efficient tool designed to help volleyball players improve their blocking, jump set, and tip skills. It is made of two metal posts that attach to the net. The posts have adjustable fasteners to adapt the height of the device. A stretchable material extends from one post to the other. There are 4-6 movable balls made of our Styrofoam attached to the material. All of the parts can be stored together in a case, making this training tool very portable for coaches and players.

Compact Switchable Adhesion Device

  1. Paul Steen
    Chemical & Biomolecular Engineering

    Cornell researchers have developed a compact, low cost, and energy efficient switchable adhesion device. The device uses a large number of very small liquid bridges that can be instantly switched on or off, grabbing and releasing an object. A truly unique technology, this device will open new possibilities in an enormous range of fields from research and defense to medicine and consumer products.

Custom Pattern Development for Garments

  1. Susan Ashdown
    Fiber Science & Apparel Design
    Anthony Reeves
    Electrical & Computer Engineering
    Hwa Kyung Song
    Fiber Science & Apparel Design

    This technology enables a reliable system and method for custom pattern development for garments. Based on 3D body scanning data and statistical analysis methods, the method uses multiple 3D measurements to categorize silhouette and profile views of the body simultaneously. This method can be utilized to classify body shapes of particular target markets, different ages, sexes, or ethnicities. A system that directly links the 3D body measurement analysis to 2D garment patterns is also introduced.

Electronic Exam and Homework Framework

  1. Pierre Gourdain
    Electrical & Computer Engineering

    This electronic framework is a useful aid for both instructors and students. It helps instructors with designing computer-run homework problems and exams, and assists students in solving these problems on their computers. The framework uses randomization of principal problem parameters, which make the answers to each problem virtually unique to each student, avoiding straightforward plagiarism. An instructor interface enables any instructor to design and write his/her own problems with no prior programming knowledge.

MADathletic, Inc.

  1. MADathletic, Inc. is commercializing a device intended for contact sport training that could improve upon a current method that uses a “sled”. Sleds are commonly used by football teams to train their linemen, but are cumbersome and heavy. MADathletic's device, known as BearClaw™, is not only light and easy to transport, but can also provide training for balance maintenance and proper hand positioning. Football teams of all ages could use the device to develop good blocking techniques and to strengthen essential muscles used in blocking.

Nanopositioning Device

  1. Amit Lal
    Electrical & Computer Engineering
    Clifford Pollock
    Electrical & Computer Engineering
    Norimasa Yoshimizu
    Electrical & Computer Engineering

    Speed and accuracy in wafer-scale nanofabrication are both severely limited by the current methods used for wafer and tool alignment. However, both can be dramatically improved through the use of a MEMS optical diffraction grating to provide a reference for alignment. The newly developed system employs a laser and a MEMS grating to project a grid on a manufacturing wafer, which is then used as a reference for controlling the movement of a nanomanufacturing probe. This technology promises to greatly improve wafer-scale nanofabrication.

Online Research Area Inspections Program

  1. Curtis Baker
    Human Resources Information Systems & Records Administration
    Laura Cecere
    Human Resources
    Brenda Coolbaugh
    Environmental Health & Safety
    Mark Fowler
    Human Resources Information Systems & Records Administration
    Jerry Gordon
    Environmental Health & Safety
    Greg Smith
    Environmental Health & Safety

    This efficient software package provides an online research area inspections program. The package consists of three integrated modules – the inspection checklist module, the corrective action module, and the summary reports module. The program allows inspection tasks to be organized and edited by a variety of users. Potential applications for the package include health and safety inspection task organization and execution for small and large facilities with multiple buildings and departments.

Robotic Positive Pressure Gripper

  1. John Amend
    Mechanical Engineering
    Hod Lipson
    Mechanical & Aerospace Engineering

    Cellular telephony is a surveillance technology. Cellular networks were designed, however unintentionally, to collect personal data, thus creating an extremely attractive source of information for law enforcement agencies and marketers. The impact of this surveillance on the users and uses of the cellular platform is becoming increasingly important, as the platform plays a prominent role in social, economic and political contexts. It is possible, however, to secure cellular networks against surveillance. This invention is a private overlay for cellular systems that protects user privacy by strictly separating equipment identity from user identity with the addition of a Public Key Infrastructure and Certification Authority (PKI).

Soy-based Nanofibers

  1. Daehwan Cho
    Fiber Science & Apparel Design
    Yong Joo
    Chemical & Biomolecular Engineering
    Anil Netravali
    Fiber Science & Apparel Design

    Researchers at Cornell have developed functional "green" fibers and associated production methods that can be used for filtration, catalysts, and protective clothing. Using various blends including soy protein isolate and polyvinyl alcohol, the materials are electrospun into nanometer-diameter fibers. Unlike currently used electrospun cellulose nanofibers, which require various toxic solvents for their manufacture, all of the materials forming the novel fibers can be processed using only water as a solvent. For the first time, products incorporating nanofibers can be "green" and fully biodegradable.

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