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Murine CD36 Monoclonal Hybridoma Cell Line License


Name: Murine CD36 Monoclonal Hybridoma Cell Line


Clone: JC63.1


Host: mouse


Immunogen: recombinant full-length murine CD36


Isotype: IgA


Positive Control: cells from adipose and heart tissue, platelets, and macrophages


Species reactivity (if known): murine, rat, and human


Applications:

Flow cytometry Yes
Immunohistochemistry Yes
Immofluorescence microscopy Yes
Immunoprecipitation Yes
Immunoprecipitation Yes
Western blotting No

Publications:

Finnemann, S.C., Silverstein, R.L. 2001. Differential roles of CD36 and av▀5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. J Exp Med 194(9) 1289-1298.

Febbraio, M., Abumrad, N.A., Hajjar, D.P., et al. 1999. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274 19055-19062.

IHC

Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, Dana R, Masli S. 2011. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med. May 9;208(5):1083-92.

IP and Microscopy

Park, Y.M., Febbraio, M. and R. L. Silverstein. 2009. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and contributes to macrophage trapping in the arterial intima. J. Clin. Invest. 119(1):136-145.

Li, W., Febbraio, M., Reddy, S.P., Yu, D.-Y., Yamamoto, M., and R. L. Silverstein. 2010. CD36 participates in a signaling pathway that regulates reactive oxygen species formation by vascular smooth muscle cells. J. Clin. Invest. 120(11):3996-4006.


Frequently asked questions:

1. Does this mAb detect soluble CD36 and was it ever tested in immunoassay applications?

Yes

2. Does the mAb work on formalin fixed, paraffin embedded tissues?

Yes, but the antigen retrieval methods must be used.



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Licensing Contact

Liyan He, Senior Technology Commercialization & Liaison Officer

lh384@cornell.edu