Weill Cornell Medical School

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Patents by Year

2006

Patent Title	Patent #	Inventor(s)
Motion Organized Simultaneous Acquisition with Interactive Control for Fast Real-Time Navigator Guided Imaging	7,123,757	Vladimir N. Kolmogorov, Yi Wang, Ramin Zabih
Electrofusion Microelectrode	7,101,703	Gianpiero D. Palermo
Detection of Nucleic Acid Sequence Differences Using Coupled Ligase Detection and Polymerase Chain Reactions	7,097,980	Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
Method of Treating Polycythemia Vera	7,094,785	Richard T. Silver
Detection of Nucleic Acid Sequence Differences Using Ligase Detection Reaction with Addressable Arrays	7,083,917	Francis Barany, Herman Blok, Monib Zirvi, Joseph P Day, Norman P. Gerry, Robert P. Hammer, Nancy E. Witkowski, Maria Kempe
Precision ultrasound measurement for intraocular lens placement	7,048,690	Jackson D. Coleman, Ronald J. Silverman, Mark J. Rondeau
Modified antibodies to prostate-specific membrane antigen and uses thereof	7,045,605	Neil Bander, Francis J. Carr, Anita Hamilton
Cyclooxygenase-2 inhibition	7,041,694	Andrew J. Dannenberg
Method of inducing neuronal production in the brain and spinal cord	7,037,493	Steven A. Goldman, Abdellatif Benraiss
Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process	7,014,994	Francis Barany, Joseph P. Day, Robert P. Hammer, Donald E. Bergstrom
Protective immunity or immunological tolerance induced with RNA particularly total cellular RNA	7,015,204	Richard D. Granstein
Isolated peptides which bind to HLA-C molecules and uses thereof	7,009,035	Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth
Methods for drug discovery, disease treatment, and diagnosis using metabolomics	7,005,255	Rima Kaddurah-Daouk, Bruce Kristal
Method and apparatus for anatomically tailored k-space sampling and recessed elliptical view ordering for bolus-enhanced 3D MR angiography	7,003,343	Richard Watts, Yi Wang, Martin R. Prince

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2005

Patent Title	Patent #	Inventor(s)
Methods for designing specific ion channel blockers	6,979,547	Xin-Yun Huang
Reversing or preventing premature vascular senescence	6,967,219	Steven S. Gross, Michael S. Goligorsky
Methods and compositions for inhibiting HIV infectivity and blocking chemokine activity	6,964,763	Andrea Rene Crombie, Ralph L. Nachman, Jeffrey C. Laurence
High fidelity thermostable ligase and uses thereof	6,949,370	Francis Barany, Weiguo Cao, Jie Tong
Method of enhancing bone density	6,939,540	Ronald G. Crystal, Chisa Hidaka, Oheneba Boachie-Adjei, Bernard A. Rawlins, Imre Kovesdi
Low dose IL-2 for potentiation of immunity	6,921,530	Kendall A. Smith
Intracardiac detection and control of repolarization alternans	6,915,156	David J. Christini, Kenneth M. Stein, Bruce B. Lerman
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof	6,911,529	Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
Measurement of protective genes in allograft rejection	6,900,015	Yingyos Avihingsanon, Nali Ma, Terry B. Strom, Miguel C. Soares, Christiane Ferran, Manikkam Suthanthiran
Betulinol derivatives	6,890,533	Arkadiy L. Bomshteyn, Premila Rathnam, Brij B. Saxena
Method and compositions for reducing cardiac dysfunctions with a selective histamine H3 receptor agonist	6,884,809	Roberto Levi, Randi B. Silver
Diagnosis of normal pressure hydrocephalus by automated processing of MR images	6,882,876	Aziz M. Ulug
DNA polymerase III holoenzyme	6,875,852	Michael E. O'Donnell
Rapidly cleavable sumo fusion protein expression system for difficult to express proteins	6,872,551	Christopher D. Lima, Elena Mossessova
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays	6,852,487	Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, Monib Zirvi

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2004

Patent Title	Patent #	Inventor(s)
IgM antibodies to the 70 kDa heat shock protein as a marker for cytomegalovirus infection	6,828,113	Steven S. Witkin
Adenovirus gene expression system	6,824,770	Erik S. Falck-Pedersen
Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder	6,815,175	Marc E. Weksler, Paul Szabo
Discovery, localization, harvest, and propagation of an FGF2 and BDNF-responsive population of neural and neuronal progenitor cells in the adult human forebrain	6,812,027	Steven A. Goldman, Maiken Nedergaard
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions	6,797,470	Francis Barany, Matthew Lubin, George Barany, Robert P. Hammer
Colon cancer antigen panel	6,794,501	Yao-Tseng Chen, Lloyd J. Old, Matthew J. Scanlan, Elisabeth Stockert
Method and apparatus for measuring and correcting motion effects using navigator echoes	6,791,323	Yi Wang, Thanh D. Nguyen
Pharmacotherapy for vascular dysfunction associated with deficient nitric oxide bioactivity	6,784,178	Steven S. Gross, Caroline L. Jones
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof	6,774,226	Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
Treatment and diagnosis of prostate cancer	6,767,711	Neil H. Bander
Automatic detection of pulmonary nodules on volumetric computed tomography images using a local density maximum algorithm	6,728,334	Binsheng Zhao
Nucleic acid encoding a fragment of bovine luteinizing hormone/chorionic gonadotropin receptor	6,723,556	Brij B. Saxena, Premila Rathnam
Detection of epithelial cell cancers and precancerous conditions	6,706,506	Lorraine J. Gudas, Xiaojio Guo
Compounds useful in pain management	6,703,483	Peter Schiller
Method for separating cells	6,692,957	Steven A. Goldman, Hong Wu

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2003

Patent Title	Patent #	Inventor(s)
REM sleep augmentation with extra-ocular light	6,669,627	Scott S. Campbell, Patricia J. Murphy
Determining viral load in double negative T cells	6,664,042	David N. Posnett
Method for isolation of cells from a solution	6,653,129	Neil H. Bander, Leonard Michael Glode, Chang In Suh
Treatment and diagnosis of cancer	6,649,163	Neil H. Bander
Enhanced biologically based chronotropic biosensing	6,650,919	Jay M. Edelberg, David J. Christini
Use of angiotensin II inhibitors to prevent malignancies associated with immunosuppression	6,641,811	Manikkam Suthanthiran, Mary Maluccio
Adenoviral vectors with tandem fiber proteins	6,599,737	Erik S. Falck-Pedersen
Sort stream stabilizer for flow cytometer	6,587,203	Christopher Colon
Thermostable DNA ligase mutants	6,576,453	Francis Barany, Jianying Luo, Marilyn Khanna, Donald E. Bergstrom
Chimeric adenovirus fiber protein	6,576,456	Thomas J. Wickham, Erik Falck-Pedersen, Petrus W. Roelvink, Joseph T. Bruder, Jason Gall, Imre Kovesdi
Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof	6,576,756	Yao-Tseng Chen, Ali Gure, Solam Tsang, Elisabeth Stockert, Elke Jger, Knuth Alexander, Lloyd J. Old
Methodology for predicting and/or diagnosing disease	6,558,955	Bruce S. Kristal, Wayne R. Matson, Paul E. Milbury
Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase	6,555,349	Michael E. O'Donnell
Method for assessing blood flow and apparatus thereof	6,547,731	D. Jackson Coleman, Katherine W. Ferrara, Dustin E. Kruse, Ronald H. Silverman
(CAG)/Q expansion disorders	6,548,243	Arthur J. L. Cooper, John P. Blass
Mammalian soluble adenylyl cyclase	6,544,768	Jochen Buck, Lonny R. Levin
Nutritional supplement for cerebral metabolic insufficiencies	6,537,969	John P. Blass
Feedback mechanism for deep brain stimulation	6,539,263	Nicholas D. Schiff, Keith Purpura, Steven Kalik
Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing	6,534,293	Francis Barany, Jianzhao Liu, Brian W. Kirk, Monib Zirvi, Norman P. Gerry, Philip B. Paty
Method of inhibiting and immune response to a recombinant vector	6,525,029	Erik S. Falck-Pedersen, Keith Elkon
Truncated forms of NY-ESO-1 protein	6,525,177	Elisabeth Stockert, Elke Jger, Yao-tseng Chen, Matthew Scanlan, Knuth Alexander, Lloyd J. Old
Multiple site delivery of adenoviral vector directly into muscle for the induction of angiogenesis	6,518,255	Todd K. Rosengart, Ronald G. Crystal
DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof	6,509,151	Lee W. Riley
Remote sensing gene therapy delivery device and method of administering a therapeutic solution to a heart	6,508,802	Todd K. Rosengart, Ronald G. Crystal
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays	6,506,594	Francis Barany, Norman P. Gerry, Nancy E. Witowski, Joseph Day, Robert P. Hammer, George Barany
Isolated peptides which bind to HLA-C molecules and uses thereof	6,506,875	Sacha Gnjatic, Lloyd J. Old, Yasuhiro Nagata, Elke Jager, Yao-Tseng Chen, Alexander Knuth

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2002

Patent Title	Patent #	Inventor(s)
Methods and compounds for treating autoimmune and vascular disease	6,491,922	John L. Ho
Treating inflammatory diseases of the head and neck with cyclooxygenase-2 inhibitors	6,486,203	Andrew J. Dannenberg
Enhanced reverse transcriptase polymerase chain assay to detect MN in patients with renal cell carcinoma	6,451,532	James M. McKiernan, Ihor S. Sawczuk, Ralph Buttyan, Neil H. Bander
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof	6,448,073	Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
Renal cancer associated antigens and uses therefor	6,440,663	Matthew J. Scanlan, Elisabeth Stockert, Yao-Tseng Chen, Lloyd J. Old, Elke Jager, Alex Knuth
Mammalian and human REC2	6,410,226	Eric B. Kmiec, William K. Holloman, Michael C. Rice, Sheryl T. Smith, Zhigang Shu
Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor	6,403,305	Marvin C. Gershengorn, Elizabeth Geras-Raaka, Daniel R. Nussenzveig
Treating cancers associated with overexpression of HER-2/neu	6,403,630	Andrew J. Dannenberg, Kotha Subbaramaiah
Human actin regulatory proteins and methods for detection, diagnosis and treatment of different stages of carcinogenesis	6,403,766	Joel D. Pardee
Isolated nucleic acid molecules associated with colon, renal, and stomach cancer and methods of using these	6,403,373	Matthew J. Scanlan, Yao-Tseng Chen, Elisabeth Stockert, Lloyd J. Old
DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof	6,399,764	Lee W. Riley
Receptors that regulate cell signaling relating to chemokines	6,365,356	Marvin C. Gershengorn
Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith	6,338,947	Ugur Sahin, zlem Treci, Yao-Tseng Chen, Lloyd J. Old, Michael Pfreundschuh
SSX family proteins	6,339,140	Ali O. Gure, Ozlem Tureci, Ugur Sahin, Solam Tsang, Matthew J. Scanlan, Alexander Knuth, Michael Pfreundschuh, Lloyd J. Old, Yao-Tseng Chen

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2001

Patent Title	Patent #	Inventor(s)
Method of inducing angiogenesis	6,329,348	Ronald G. Crystal, Todd K. Rosengart
Minimally invasive gene therapy delivery and method	6,322,536	Todd K. Rosengart, Ronald G. Crystal
Composition for tissue welding and method of use	6,323,037	Antonio Lauto, Dix P. Poppas
Method and apparatus for ultrasound corneal scanning	6,315,727	D. Jackson Coleman, Dan Z. Reinstein, Ronald H. Silverman
High fidelity detection of nucleic acid differences by ligase detection reaction	6,312,892	Francis Barany, Jianying Luo, Marilyn Khanna, Donald E. Bergstrom
Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof	6,297,364	Yao-Tseng Chen, Ali Gure, Solam Tsang, Elisabeth Stockert, Elke Jager, Knuth Alexander, Lloyd J. Old
Treating cancers associated with overexpression of class I family of receptor tyrosine kinases	6,291,496	Andrew J. Dannenberg, Kotha Subbaramaiah
Isolated nucleic acid molecules encoding SSX family members and thereof	6,291,658	Ali O. Gure, Ozlem Tureci, Ugur Sahin, Solam Tsang, Matthew J. Scanlan, Alexander Knuth, Michael Pfreundschuh, Lloyd J. Old, Yao-Tseng Chen
Methods for determining presence of cancer in a sample by determining expression of an SSX gene	6,287,756	Ozlem Tureci, Yao-Tseng Chen, Ugur Sahin, Ali O. Gure, Lloyd J. Old, Michael Pfreundschuh
Human origin of replication complex genes and uses thereof	6,281,347	Michael O'Donnell, Frank Dean, Irena Bruck
Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis	6,274,581	Steven S. Gross
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions	6,268,148	Francis Barany, Matthew Lubin, Phillip Belgrader
Isolated nucleic acid molecule encoding an esophageal cancer associated antigen	6,255,470	Yao-tseng Chen, Matthew Scanlan, Ali Gure, Lloyd J. Old
Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample	6,251,603	Elke Jager, Elisabeth Stockert, Lloyd J. Old, Alexander Knuth
Method for separating cells	6,245,564	Steven A. Goldman, Hong Wu
Recombinant helix modification recognition proteins and uses thereof	6,232,095	Eric B. Kmiec, William K. Holloman, David Gerhold
Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase	6,231,894	Jonathan S. Stamler, Brian J. Day, Steven S. Gross, Owen W. Griffith
Method for performing magnetic resonance angiography with dynamic k-space sampling	6,230,040	Yi Wang, Howard M. Lee
DNA molecule fragments encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof	6,224,881	Lee W. Riley, Pele Chong
Process for reconstituting the polymerase III* and other subassemblies of E. coli DNA polymerase III holoenzyme from peptide subunits	6,221,642	Michael E. O'Donnell
DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof	6,214,543	Lee W. Riley
Rec 2 kinase	6,210,916	Pamela A. Havre, Michael C. Rice, William K. Holloman, Eric B. Kmiec
Method of screening agents as candidates for drugs or sources of drugs	6,200,760	Andrew J. Dannenberg, Kotha J. Subbaramaiah, David S. Pasco
Coronary magnetic resonance angiography using motion matched acquisition	6,198,959	Yi Wang
Substituted isoquinolines as ultra short acting neuromuscular blockers	6,187,789	Eric Cleveland Bigham, Grady Evan Boswell, John Joseph Savarese, Roy Archibald Swaringen, Jr., Sanjay Shashikant Patel, Eric Eugene Boros, Robert Anthony Mook, Jr., Vincente Samano
Methods of evaluating transplant rejection	6,187,534	Terry B. Strom, Lauro Vasconcellos, Manikkam Suthanthiran
DNA molecule conferring on Mycobacterium tuberculosis resistance against antimicrobial reactive oxygen and nitrogen intermediates	6,177,086	Lee W. Riley, Carl F. Nathan, Sabine Ehrt
Substituted isoquinolines as ultra short acting neuromuscular blockers	6,177,445	Eric Cleveland Bigham, Grady Evan Boswell, John Joseph Savarese, Roy Archibald Swaringen, Jr., Sanjay Shashikant Patel, Eric Eugene Boros, Robert Anthony Mook, Jr., Vincente Samano
REC2 kinase	6,174,694	Pamela A. Havre, Michael C. Rice, William K. Holloman, Eric B. Kmiec

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